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US 11,077,177 B2Granted
Universal cancer vaccine
OwnerMaurizio Zanettiinventor
Life of this patent
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Abstract
Described herein are compositions of matter and methods for treating cancer. The compositions comprise altered human telomerase polypeptides containing T cell epitopes that have been altered to increase immunogenicity. The methods comprise administration of the polypeptides or nucleic acids, such as DNA or RNA encoding the polypeptides, to individuals afflicted with, or at risk of, developing cancer.
Claims11
An altered human telomerase polypeptide with at least 90% identity to the sequence set forth in SEQ ID NO:
- 1, wherein the altered human telomerase polypeptide comprises at least five or more amino acid substitutions that are at position R19, L22, R132, L152, D444, K492, E555, L556, T564, R572, R577, D637, L675, E727, R742, T765, R811, L840, G847, T874, L940, K981, V997, or P1020 of telomerase.
Dependencies are inferred from the claim text.