Loading patent…
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsPeter I. Lelkes, Yah-El H. Har-el, Cezary Marcinkiewicz, Philip Lazarovici, Sogol Moaiyed Baharlou, Jonathan A. Gerstenhaber
Estimating the term…
Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.
A composition for inducing wound healing and tissue regeneration, wherein the composition comprises a bioactive peptide component of a soy protein isolate (SPI), wherein the SPI comprises a water soluble soy protein isolate (WSsoy), and wherein the composition comprises a protein Fraction 5 eluted during separation of WSsoy using reverse phase-high pressure liquid chromatography (RP-HPLC) using C18 with a linear gradient of elution (0-80% acetonitrile (ACN)) over 45 minutes, wherein Fraction 5 has a retention time of about 25-35 minutes and a zeta potential of about 17.9 mV.
A composition for inducing wound healing and tissue regeneration, wherein the composition comprises a bioactive peptide component of a soy protein isolate (SPI), wherein the SPI comprises a water soluble soy protein isolate (WSsoy), and wherein the composition comprises a protein Fraction 9 eluted during separation of WSsoy using reverse phase-high pressure liquid chromatography (RP-HPLC) using C18 with a linear gradient of elution (0-80% acetonitrile (ACN)) over 45 minutes, wherein Fraction 9 has a retention time of about 35-40 minutes and a zeta potential of about 34.2 mV, and contains β-conglycinin or fragments thereof having an Leu-Asp-Val (LDV) motif.
Dependencies are inferred from the claim text.