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US 11,077,141 B2Granted
Anti-tumor T cell immunity induced by high dose radiation
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSamuel Strober, Alexander Filatenkov
Life of this patent
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Abstract
Cancer treatment is provided, by irradiating an individual with a localized, high single dose or short course of doses at a primary tumor site; collecting T cells from the individual after a period of time sufficient activation of an anti-tumor response; treating the individual with an effective dose of dose of chemotherapy; and reintroducing the T cell population back to the individual.
Claims23
A method for treating a cancer in a subject, the method comprising:
- a. activating T cells with a high dose of localized radiation at a tumor site;
- b. collecting a population of cells comprising the activated T cells and hematopoietic stem cells;
- and
- c. administering the collected population of cells to the subject, thereby treating the cancer.
1 more element
Dependencies are inferred from the claim text.