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AssigneeDuke University
InventorsBarton F. Haynes, Sallie Permar, M. Anthony Moody, Feng Gao, Hua-Xin Liao, Georgia Tomaras, David C. Montefiori
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The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
A method for reducing maternal to child HIV-1 transmission by inducing or boosting V3-specific or CD4 binding site-specific HIV-1 antibody responses in a pregnant female subject infected with HIV-1 comprising administering to the subject an immunogenic composition comprising an HIV-1 envelope in an amount sufficient to effect such induction, wherein the composition comprises clade B gp120 HIV-1 envelope and clade C gp120 HIV-1 envelope and wherein the subject's anti-V3 IgG concentration above 37 micorgram/ml in plasma is correlated with reduced risk of maternal to child transmission.
Dependencies are inferred from the claim text.