Nicotinoyl riboside compositions and methods of use
AssigneeCornell University
InventorsAnthony A. Sauve, Tianle Yang Redanz
Life of this patent
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Abstract
The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
Claims19
A method of reducing cell proliferation, which method comprises administering to proliferating cells a proliferation-reducing amount of a compound of formula (I):
- and salt complexes thereof, wherein R is selected from the group consisting of alkylamino, substituted alkylamino, arylalkylamino, dialkylamino, substituted dialkylamino, hydroxylamino, substituted hydroxylamino, O-alkyloxyamino, substituted O-alkyloxyamino, aminooxy, substituted aminoxy, N-alkylaminooxy, substituted N-alkylaminoxy, hydrazino, substituted hydrazino, alkylhydrazino, and substituted alkylhydrazino,
- whereby the cell proliferation is reduced.
A method of treating cancer in a mammal in need thereof, wherein the cancer is a cancer responsive to treatment with an antiproliferative agent, comprising administering to the mammal an effective amount of a compound of formula (I):
- and salt complexes thereof, wherein R is selected from the group consisting of alkylamino, substituted alkylamino, arylalkylamino, dialkylamino, substituted dialkylamino, hydroxylamino, substituted hydroxylamino, O-alkyloxyamino, substituted O-alkyloxyamino, aminooxy, substituted aminoxy, N-alkylaminooxy, substituted N-alkylaminoxy, hydrazino, substituted hydrazino, alkylhydrazino, and substituted alkylhydrazino in combination with an antiproliferative agent,
- whereby the cancer is treated.
Dependencies are inferred from the claim text.