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US 11,077,116 B2Granted
Isoxazole derivatives as inducers of fetal hemoglobin in erythroid precursor cells from beta-thalassemic patients
AssigneeRare Partners Srl
InventorsIlaria Lampronti, Roberto Gambari, Daniele Simoni
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Abstract
The invention refers to the use of isoxazole derivatives to prepare medicament able to induce fetal hemoglobin (HbF) synthesis in β-thalassemia and sickle cell disease (SCD) patients.
Claims5
A method to induce fetal hemoglobin for therapeutic treatment of thalassemia and sickle cell disease in patients in need thereof with compounds of formula I
- wherein R1 is C1-C3 alkyl or chlorine, fluorine, bromine;
- R2 is hydroxy or methyl;
- X is a C1-C4 alkylamino group or C1-C4 fluoroalkylamino group;
- Y is a C2-C4 acyl group, a benzoyl group, optionally substituted with one or more methoxy, heteroaryl moieties, or a group with the following formula:
1 more element
Dependencies are inferred from the claim text.