Formulation and treatment methods
AssigneeProdrugxtend Pty Ltd
InventorsTimothy Florin, Amirali Popat, Siddharth Jambhrunkar
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Abstract
The invention relates to pharmaceutical compositions comprising 6-thioguanidine (6-TG) wherein the composition is formulated for release of 6-TG in the distal intestine. Methods for treating a disease or condition of the distal ileum that responds to 6-TG wherein the 6-TG is released in the distal intestine are also disclosed.
Claims16
A pharmaceutical composition comprising 6-TG and a homogeneous erodible hydrophilic polymer matrix, wherein the composition is formulated for oral administration and provides release of at least 35% of the 6-TG in vitro at about pH 6 to about pH 7.5 after approximately 12 hours.
Dependencies are inferred from the claim text.