Compositions and methods for treating and preventing metabolic disorders
AssigneeTufts Medical Center, Inc.
InventorMiaofen G. Hu
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions and methods for treating or preventing metabolic disorders. In particular, provided herein are compositions, methods, and uses of Cyclin-dependent Kinase 6 (CDK6) inhibitors for treating and preventing metabolic diseases (e.g., type II diabetes, obesity, metabolic syndrome, elevated blood pressure, cardiovascular diseases, elevated fasting plasma glucose, and high serum triglycerides).
Claims11
A method of treating metabolic disease in a subject diagnosed with a metabolic disease selected from the group consisting of type II diabetes, obesity, metabolic syndrome, elevated blood pressure, cardiovascular diseases, elevated fasting plasma glucose, and high serum triglycerides, comprising:
- administering a CDK6 inhibitor to said subject,
- wherein said administering reduces one or more symptoms of said metabolic disease.
A method of treating metabolic disease in a subject diagnosed with a metabolic disease selected from the group consisting of type II diabetes, obesity, metabolic syndrome, elevated blood pressure, cardiovascular diseases, elevated fasting plasma glucose, and high serum triglycerides, comprising:
- administering a CDK6 inhibitor to said subject, wherein said CDK6 inhibitor is selected from the group consisting of PD0332991, LEE011, AT7519, JNJ-7706621, P276-00, and their pharmaceutically acceptable salts thereof,
- wherein said administering reduces one or more symptoms of said metabolic disease.
Dependencies are inferred from the claim text.