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US 11,077,106 B2Granted
Cancer treatment
AssigneeJanssen Pharmaceutica NV
InventorsKim Stuyckens, Juan Jose Perez Ruixo, Peter Marie Z. De Porre, Anjali Narayan Avadhani, Yohann Loriot, Arlene O. Siefker-Radtke
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Abstract
The present invention provides a method for the treatment of cancer with erdafitinib.
Claims23
A method for the treatment of urothelial cancer harboring at least one FGFR genomic alteration, which method comprises:
- a) administering to a subject in need thereof, 8 mg of erdafitinib daily on a continuous basis;
- b) measuring the serum phosphate levels of the subject on a treatment day during the first cycle of erdafitinib treatment;
- and
- c-1) when the serum phosphate levels are <5.5 mg/dL, erdafitinib is administered in an amount of 9 mg daily, on a continuous basis;
- or
- c-2) when the serum phosphate levels range from and including 5.5 mg/dL to <7 mg/dL, erdafitinib is further administered in an amount of 8 mg daily, on a continuous basis;
- or
- c-3) when the serum phosphate levels are ≥7 mg/dL, the erdafitinib treatment is interrupted temporarily.
5 more elements
Dependencies are inferred from the claim text.