Methods of treating diabetes by administering a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor
AssigneeMerck Sharp & Dohme Corp.
InventorsHong-Ping Guan, Jose M. Castro-Perez, Harry R. Davis, Samuel E. Engel, Douglas G. Johns, Songnian Lin, Stephen F. Previs, Thomas P. Roddy, Liangsu Wang, Sheng-Ping Wang, Yusheng Xiong
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Abstract
Use of a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor for the treatment of diabetes and related conditions is disclosed.
Claims15
A method of treating diabetes in a mammalian subject having an LDL cholesterol plasma level of less than 100 mg/dL, which comprises administering to said mammalian subject:
- (a) a glucagon receptor antagonist, and
- (b) a cholesterol absorption inhibitor,
- wherein the subject is not further being treated with a statin.
A method of reducing hyperglycemia in a mammalian subject having an LDL cholesterol plasma level of less than 100 mg/dL, which comprises administering to said mammalian subject:
- (a) a glucagon receptor antagonist, and
- (b) a cholesterol absorption inhibitor,
- wherein the subject is not further being treated with a statin.
Dependencies are inferred from the claim text.