Compositions and methods for the treatment of metabolic conditions

A method of elevating blood oxygen in a subject suffering from hypoxia, the method comprising elevating the pO2 in the venous blood in the subject suffering hypoxia, comprising administering to the subject a stable therapeutic composition comprising an intravenous buffer solution comprising an equilibrium product of mixing at least one pharmaceutical grade acid with at least one pharmaceutical grade pH buffering agent in a sterile aqueous solution,

• wherein the pharmaceutical grade acid is selected from the group consisting of hydrochloric acid, ascorbic acid, dehydroascorbic acid, acetic acid, citric acid, lactic acid, phosphoric acid, and a combination of two or more thereof,
• wherein the composition is administered in an amount effective to provide metabolic corrections that promote vasodilation, reduction of intracellular accrual of Ca2+, or stimulate renal and respiratory action to shift blood pH towards alkaline, thereby elevating the subject's blood oxygen to alleviate the hypoxia,
• wherein the concentration of the pharmaceutical grade acid and the pharmaceutical grade pH buffering agent in the buffer solution is sufficient to provide a total titratable acid content of from 60 mmol/L to 3,000 mmol/L when administered to a subject, and
• wherein the selection of the pharmaceutical grade acid and the pharmaceutical grade pH buffering agent is effective to provide a buffer solution pH of between 4 and 7.7.