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US 11,077,086 B2Granted
Solid dosage form composition for buccal or sublingual administration of cannabinoids
AssigneePharmaceutical Productions Inc.
InventorJohn A. McCarty
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Abstract
The present invention relates to solid dosage forms of cannabinoid pharmaceutical formulations comprising a solvated cannabinoid for buccal or sublingual administration, and methods of making and using the same.
Claims18
A pharmaceutical composition, comprising:
- a pharmaceutically-acceptable adsorbent, and adsorbed thereto a cannabinoid solution comprising a mixture of ethanol and a cannabinoid selected from the group consisting of delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD) and mixtures thereof;
- wherein
- the pharmaceutical composition is a solid dosage form;
- the solid dosage form is a tablet, powder, or film;
- dissolution of the cannabinoid occurs within 300 seconds in 0.1 M phosphate buffer, pH 6.8, with 2% polysorbate 20;
- the pharmaceutically-acceptable adsorbent is silica;
- the cannabinoid is present in an amount from about 0.1 mg to about 150 mg;
- and
- the weight/weight ratio of silica:cannabinoid solution is from about 1:0:0.5 to about 1.0:5.0;
- and
- the cannabinoid solution in the solid dosage form comprises from about 5 wt % to about 95 wt % of ethanol by weight of the cannabinoid solution.
8 more elements
A composition, comprising:
- a solid dosage form of a pharmaceutically acceptable silica, and adsorbed thereto a solvated cannabinoid, the solvated cannabinoid consisting essentially of:
- a cannabinoid;
- and
- ethanol;
- wherein the solvated cannabinoid in the solid dosage form is from about 5 wt % to about 95 wt % ethanol by weight of the solvated cannabinoid.
2 more elements
Dependencies are inferred from the claim text.