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AssigneeSolutex NA LLC
InventorsGerhardus Lucas Bannenberg, Charles Nicholas Serhan, Fernando Moreno Egea
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The present invention encompasses oils that have anti-inflammatory or resolution-stimulating activity that contain or are enriched with Specialized Proresolving Mediators (SPM) or SPM precursors, which originate from an oil obtained from organisms containing long chain omega-3 polyunsaturated fatty acids, such as fish, crustaceae, algae, and mollusks. The invention also encompasses a method for the production of these oils, and the utilization of the oils for nutritional supplements, pharmaceutical formulations, and cosmetic formulations, which can be employed for treating an inflammatory condition.
A method of reducing inflammation or stimulating resolution of inflammation in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition comprising 18-hydroxy-eicosapentaenoic acid (18-HEPE), 17-hydroxy-docosahexaenoic acid (17-HDHA), 14-hydroxy-docosahexaenoic acid (14-HDHA), 10-hydroxy-docosahexaenoic acid (10-HDHA), and 4-hydroxy-docosahexaenoic acid (4-HDHA), wherein 17-HDHA is present in an amount of at least 100 mg/L.
A method of stimulating resolution of inflammation in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition comprising fatty acids including 18-hydroxy-eicosapentaenoic acid (18-HEPE), 17-hydroxy-docosahexaenoic acid (17-HDHA), 14-hydroxy-docosahexaenoic acid (14-HDHA), 10-hydroxy-docosahexaenoic acid (10-HDHA), 4-hydroxy-docosahexaenoic acid (4-HDHA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), wherein the fatty acids are in ethyl ester form and the 17-HDHA is present in an amount of at least 100 mg/L.
Dependencies are inferred from the claim text.