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US 11,077,082 B2Granted
Composition and method for dual targeting in treatment of neuroendocrine tumors
AssigneeNanopharmaceuticals LLC
InventorsShaker Mousa, Mehdi Rajabi, Ozlem O. Karakus
Life of this patent
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Abstract
Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone αvβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.
Claims22
A composition comprising:
- a compound of a general formula:
- or a salt thereof;
- wherein R1, R2, R3, and R4 are each independently selected from the group consisting of hydrogen, iodine, fluorine, bromine, a methoxy group, a nitro group, an amine group, and a nitrile group;
- wherein R5, R6, R7, and R8 are each independently selected from the group consisting of hydrogen, iodine, and an alkane group;
- and
- n1≥0;
- n2≥1;
- and
5 more elements
A method for dual targeting of tumor cells, comprising:
- administering a composition comprising:
- a compound of a general formula:
- or a salt thereof;
- wherein R1, R2, R3, and R4 are each independently selected from the group consisting of hydrogen, iodine, fluorine, bromine, a methoxy group, a nitro group, an amine group, and a nitrile group;
- wherein R5, R6, R7, and R8 are each independently selected from the group consisting of hydrogen, iodine, and an alkane group;
- and
- n1≥0;
- n2≥1;
- and
6 more elements
Dependencies are inferred from the claim text.