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US 11,077,077 B1Granted
Therapeutic compounds, formulations, and uses thereof
AssigneeTvardi Therapeutics, Inc.
InventorsImran Alibhai, Sofia De Achaval, Beverly C. Langevin, Tian Zhou
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Abstract
Provided herein are compositions, formulations, and (e.g., oral) dosage forms comprising a compound of Formula (I). In specific instances, such compositions comprise an emulsifier, a solubilizer, a polyethylene glycol, a surfactant, and an antioxidant. In some instances, such compositions are useful for the treatment of fibrosis, cancer, and/or chronic inflammation.
Claims19
A pharmaceutical composition comprising:
- a. at least 50 mg of a compound of Formula (I):
- b. a glyceride emulsifier present in the composition in a weight ratio of compound of Formula (I) to emulsifier of about 1:1;
- c. a solubilizer present in the composition in a weight ratio of compound of Formula (I) to solubilizer of about 1:3, wherein the solubilizer is polyoxyl castor oil;
- d. a polyethylene glycol (PEG) present in the composition in a weight ratio of compound of Formula (I) to polyethylene glycol of about 1:4;
- e. a surfactant present in the composition in a weight ratio of compound of Formula (I) to surfactant of about 1:2, wherein the surfactant is polysorbate;
- and
- f. an antioxidant present in the composition in a weight ratio of compound of Formula (I) to antioxidant of about 20:1.
4 more elements
Dependencies are inferred from the claim text.