Pharmaceutical composition
AssigneeMexichem Fluor S.A. De C.V.
InventorsStuart Corr, Timothy James Noakes
Life of this patent
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Abstract
A pharmaceutical composition is described. The composition comprises: (i) a drug component comprising at least one salmeterol compound selected from salmeterol and the pharmaceutically acceptable derivatives thereof; and (ii) a propellant component comprising 1,1-difluoroethane (HFA-152a).
Claims16
A method of improving the stability of a pharmaceutical composition comprising a propellant component and a drug component comprising at least one salmeterol compound selected from salmeterol and the pharmaceutically acceptable salts thereof, said method comprising:
- using a propellant component at least 90 weight % of which is 1,1-difluoroethane (HFA-152a), and
- selecting the components and conditions for the preparation of the pharmaceutical composition to maintain the water content of the pharmaceutical composition below 500 ppm based on the total weight of the pharmaceutical composition.
A method of improving the stability of a pharmaceutical composition comprising a propellant component and a drug component comprising at least one salmeterol compound selected from salmeterol and the pharmaceutically acceptable salts thereof, said method comprising:
- using a propellant component at least 90 weight % of which is 1,1-difluoroethane (HFA-152a), wherein the oxygen content of the resulting pharmaceutical composition is below 1000 ppm based on the total weight of the pharmaceutical composition.
Dependencies are inferred from the claim text.