Methods of stabilizing epinephrine

A method of stabilizing a pharmaceutical composition comprising from about 1% to about 12% w/w epinephrine, from about 10% to about 60% w/w ethanol, from about 2% to about 20% w/w propylene glycol, from about 0.001% to about 0.02% w/w benzalkonium chloride and from about 0.01% to about 0.1% w/w edetate disodium dihydrate comprising the steps of:

• a. filling a container with the pharmaceutical composition under a vacuum or a gas overlay;
• b. closing the container;
• c. placing the closed container in a holder and actuator to create an assembled device;
• d. placing the assembled device in a secondary packaging system under one or more conditions selected from the group consisting of under a gas overlay, with an oxygen absorbing means and with oxygen indicator;
• and
• e. sealing the secondary packaging system,
• wherein the container is selected from the group consisting of a glass vial, a plastic vial, a glass bottle and a plastic bottle and the secondary packaging system is selected from the group consisting of a pouch and a blister package and wherein w/w denotes weight to total weight of the composition.