US 11,077,074 B2Granted

Compositions and methods useful for treatment of respiratory illness

AssigneeThe Procter & Gamble Company

InventorsKelly Lee Schmeichel, Jayant Eknath Khanolkar, Douglas William Gledhill, Susan Elaine Criss, Niranjan Ramji, Elaine Rose Costeines

Life of this patent

Estimating the term…

patentgrep

Loading patent…

Abstract

Disclosed are compositions including phenylephrine, its free and addition salt forms, and mixtures thereof, alone, or in combination with other pharmaceutical actives. The compositions have a pH of about 2 to about 5 and are substantially free of aldehydes. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its free and addition salt forms, and mixtures thereof alone, or in combination with other pharmaceutical actives, wherein the composition has a pH of from about 2 to about 5 and is substantially free of aldehydes.

Claims22

Dependent claims

A liquid composition comprising:

(a) from about 0.001% to about 0.5% of phenylephrine hydrochloride, by weight of the liquid composition;
(b) one or more additional actives selected from the group consisting of dextromethorphan, acetaminophen, doxylamine, guaifenesin, the free and addition salts thereof, and mixtures thereof;
(c) a flavor which comprises one or more non-aldehydic aesthetic agents;
(d) a sweetener selected from the group consisting of sugar alcohols, artificial sweeteners, and mixtures thereof;
wherein the sugar alcohols are selected from the group consisting of glycerin, sorbitol, maltitol, mannitol, and mixtures thereof and the artificial sweeteners are selected from the group consisting of sodium saccharine, acesulfame potassium, sucralose, aspartame, monoammonium glycyrrhizinate, neohesperidin dihydrochalcone, thaumatin, neotame, cyclamates, and mixtures thereof;
(e) a solvent selected from the group consisting of water, ethanol, propylene glycol, and mixtures thereof;
(f) a chelating agent selected from the group consisting of disodium and calcium salts of ethylene diamine tetraacetic acid (EDTA), terasodium EDTA, sodium hexametaphosphate (SHMP), citric acid, phosphoric acid, di(hydroxyethyl)glycine, 8-hydroxyquinoline, and mixtures thereof;
and
(g) a reducing agent;
wherein the liquid composition is a solution;
wherein the liquid composition has a pH of from about 2 to about 5;
wherein the liquid composition comprises a ratio of propylene glycol to glycerin of 1:1 to 3:1;
and wherein the liquid composition comprises less than about 0.05% of total aldehydes, by weight of the liquid composition.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/011,700Filed 19 Jun 2018 · continuation
Priority: 21 Apr 2006
Published: US 2018/0338933 A129 Nov 2018
Granted: 3 Aug 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 31/137
Having aromatic rings , e.g. ketamine, nortriptyline: arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
A61K 31/473
Quinolines; Isoquinolines: ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
A61K 31/485
Quinolines; Isoquinolines: morphinan derivatives, e.g. morphine, codeine
A61K 31/495
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with two or more nitrogen atoms as the only ring…

Family

Application11/408,299Parent of this continuation · filed 21 Apr 2006
US 2018/0338933 A1Pre-grant publication · published 29 Nov 2018
US 10,022,339 B2Parent of this continuation
US 2007/0249566 A1Published application
US 11,077,074 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

Building an agent or pulling many patents? Use the API or MCP server instead of scraping pages. Get an API key