Apparatus and method for cryogranulating a pharmaceutical composition

A cryogranulation system comprising:

• a dispenser assembly, a reservoir for holding a source of a cooling agent, a pump assembly for delivering a pharmaceutical suspension;
• a pump system for delivering the cooling agent, a transport system for transporting formed pellets to a receptacle and an exhaust system;
• wherein the dispenser assembly comprises a housing and a dispenser subassembly which comprises a first element having one or more inlet ports, a second element having a plurality of dispenser ports;
• and a securing mechanism for holding the first and second elements together;
• said dispenser subassembly adaptable to said housing and having an internal volume for receiving and dispensing the pharmaceutical suspension to be pelletized, wherein the dispenser ports of the dispenser subassembly each include an upper conduit of a first inner diameter and a lower conduit of a second inner diameter, wherein the dispenser ports of the dispenser subassembly include first and second rows of dispenser ports, the rows being disposed perpendicularly with respect to the flow of cooling agent, wherein the first and second rows of dispenser ports are angled with respect to vertical, wherein the dispenser ports of the first row are disposed at opposite angles with respect to the dispenser ports of the second row, and wherein the dispenser assembly includes a heater configured to prevent the pharmaceutical suspension from freezing during dispensing.