Back to results
US 11,077,057 B2Granted
Polymer-grafted nanobins
AssigneeNorthwestern University
InventorsAnthony J. Chipre, SonBinh T. Nguyen
Life of this patent
Estimating the term…
Abstract
Provided herein are small unilamellar vesicles with surface-displayed polymer moieties, and methods of use and manufacture thereof. In particular, provided herein are polymer-grafted nanobins, and methods of drug delivery therewith.
Claims14
A method of drug delivery comprising:
- administering a polymer-grafted nanobin (PGN) to a subject, wherein the PGN comprises a small unilamellar vesicle (SUV) between 15 and 50 nm in diameter, wherein a phospholipid-based bilayer of the SUV comprises surface-exposed polymers extending therefrom, wherein the surface-exposed polymers comprise poly(acrylic acid) extending from cholesterol-terminated poly(acrylic acid) (Chol-PAA), wherein the cholesterol portion of the Chol-PAA is inserted into the bilayer, wherein the surface-exposed polymers are not cross-linked, and wherein the PGN encompasses a molecular payload comprising one or more therapeutic agents.
Dependencies are inferred from the claim text.