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US 11,077,051 B2Granted
Shear-thinning therapeutic composition, and related methods
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsXiaochu Ding, Jin Gao, Yadong Wang
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Abstract
A shear-thinning therapeutic composition is provided along with methods of making and using the therapeutic composition.
Claims20
A shear-thinning therapeutic composition, comprising:
- silicate platelets;
- a gelling agent non-covalently linking the platelets to form a shear-thinning composition;
- and
- a therapeutic agent that binds non-covalently to the gelling agent and that is complexed non-covalently with the gelling agent wherein the gelling agent is a sulfated or sulfamated polymer, polysaccharide, or glycosaminoglycan.
1 more element
A method of making a composition for delivery of a therapeutic agent, comprising:
- mixing a gelling agent with a therapeutic agent that is a binding partner of the gelling agent to produce a complex of the gelling agent and the therapeutic agent;
- and
- mixing the complex of the gelling agent and the therapeutic agent with silicate platelets to produce a shear-thinning hydrogel
- wherein the gelling agent non-covalently links the platelets and is a sulfated or sulfamated polymer, polysaccharide, or glycosaminoglycan;
- and
- wherein the therapeutic agent binds non-covalently to the gelling agent and is complexed non-covalently with the gelling agent.
3 more elements
Dependencies are inferred from the claim text.