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AssigneesThe Florida International University Board of Trustees, University of Miami
InventorsSohini Roy Choudhury, Yogeswaran Umasankar, Shekhar Bhansali, Robert S. Kirsner, Hadar A. Lev-Tov
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The subject invention provides sensor systems that can detect biomarkers related to wound healing (e.g., uric acid, adenosine, arginine and/or xanthine). In one embodiment, the subject invention pertains to materials and methods for monitoring biomarkers non-invasively in a wound and a biofluid (e.g., sweat) in the proximity of the wound, optionally, including other physiological fluids. Skin based, non-invasive enzymatic electrochemical biosensor on a wearable platform (e.g., sweat patch) that can evaluate the healing of wounds through assessment of its biomarker levels are provided. This non-invasive detection from physiologically biofluids can reduce or eliminate occlusion effects.
A flexible enzymatic electrochemical sensor comprising a working electrode, a reference electrode and a counter electrode, the working electrode being functionalized with an enzyme, the enzyme being selected from uricase (UOx), adenosine deaminase, arginase and xanthine oxidase (XO), the working electrode being further functionalized with a polymer and catalytic metal nano-structures selected from nano-flakes, nano-rods, and nano-wires.
A flexible enzymatic electrochemical sensor, comprising a working electrode, a reference electrode and a counter electrode, the working electrode being a carbon electrode functionalized with uricase (UOx), PVA-SbQ, and catalytic nano-wires on the surface, UOx being entrapped in the matrix of PVA-SbQ, and the flexible enzymatic electrochemical sensor further comprising FCA.
Dependencies are inferred from the claim text.