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US 11,029,446 B2Granted
Method for producing MPS-compatible water gradient contact lenses
AssigneeAlcon Inc.
InventorsYongxing Qiu, John Dallas Pruitt, Newton T. Samuel
Life of this patent
Estimating the term…
Abstract
The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a 30-days lens care regime.
Claims23
A process for producing contact lenses, comprising the steps of:
- (a) obtaining a contact lens precursor which is a coated contact lens and has a first polyquaternium-1 uptake (“PUo”), wherein the coated contact lens comprises a lens bulk material completely covered with an anchor layer of a polyanionic polymer and an outer surface hydrogel layer covalently attached to the anchor layer, wherein the polyanionic polymer comprises at least 60% by mole of repeating units of at least one carboxyl-containing vinylic monomer;
- and
- (b) heating the contact lens precursor in an aqueous solution in the presence of at least one polyaziridine to and at a temperature from about 30° C. to about 140° C. for a period of time sufficient to obtain the contact lens having a second polyquaternium-1 uptake (“PUpz”), wherein the polyaziridine having a number average molecular weight of about 2000 Dalton or less and at least two aziridine groups each of which is a mono-valent radical of formula
- in which R1 is hydrogen, methyl or ethyl, wherein (PUo-PUpz)/PUo is at least 60%.
1 more element
A process for producing contact lenses, comprising the steps of:
- (a) obtaining a contact lens precursor which is a coated contact lens and has a first polyquaternium-1 uptake (“PUo”), wherein the coated contact lens comprises a lens bulk material completely covered with at least one layer of a polyanionic polymer, wherein the polyanionic polymer comprises at least 60% by mole of repeating units of at least one carboxyl-containing vinylic monomer;
- and
- (b) heating the contact lens precursor in an aqueous solution in the presence of at least one polyaziridine to and at a temperature from about 30° C. to about 140° C. for a period of time sufficient to obtain the contact lens having a second polyquaternium-1 uptake (“PUpz”), wherein the polyaziridine having a number average molecular weight of about 2000 Dalton or less and at least two aziridine groups each of which is a mono-valent radical of formula
- in which R1 is hydrogen, methyl or ethyl, wherein (PUo-PUpz)/PUo is at least 60%.
1 more element
Dependencies are inferred from the claim text.