Method of treating cervical neoplasia in patients infected with human papilloma virus

A method for treating cervical neoplasia in a subject infected with human papilloma virus (HPV), the method comprising:

• (a) detecting an HPV status from a cervical sample obtained from the subject, wherein the HPV is HPV type 6, 11, 16, 18, 31, 33, and/or 51;
• (b) measuring a level of a CXCL12 polypeptide having a molecular weight greater than about 10 kD or 11 kD in a cervical neoplasia sample of the subject;
• (c) comparing the level of the CXCL12 polypeptide in the cervical neoplasia sample of the subject to a first reference level and a second reference level;
• and
• (d) administering a less aggressive treatment to the subject identified as having a pre-invasive cervical neoplasia, wherein the pre-invasive cervical neoplasia comprises a level in the cervical neoplasia sample above the first reference level and below the second reference level, or administering a more aggressive treatment to the subject identified as having an invasive stage of cervical neoplasia, wherein the invasive stage of cervical neoplasia comprises a level in the cervical neoplasia sample above both the first reference level and the second reference level,
• wherein the first reference level is an increase of less than about 3-fold compared to a control sample;
• wherein the second reference level is an increase of more than 3-fold compared to the control sample;
• wherein the less aggressive treatment regimen is selected from the group consisting of loop electrical excision procedure (LEEP), trachelectomy, and hormonal therapy;
• and
• wherein the more aggressive treatment regimen is selected from the group consisting of hysterectomy, radiation therapy, and chemotherapy;
• thereby treating the cervical neoplasia in the subject.