PAH antibodies and uses thereof

A recombinant antibody or fragment thereof that specifically binds to a polycyclic aromatic hydrocarbon (PAH), wherein the PAH is selected from the group consisting of naphthalene, acenapthene, acenapthylene, phenanthrene, fluorene, anthracene, benz[a]anthracene, chrysene, pyrene, fluoranthene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, indeno[1,2,3-cd]pyrene, benzol[ghi]perylene, and dibenz[a,h]anthracene,

• wherein the recombinant antibody or fragment thereof comprises
• a) a heavy chain with three CDRs comprising the amino acid sequences GYTFTSYWMH (SEQ ID NO:
• 60), EINPRNGRSNYNEKFKN (SEQ ID NO:
• 61), and DGGDY (SEQ ID NO:
• 62), respectively, and a light chain with three CDRs comprising the amino acid sequences KASQDVGTAVA (SEQ ID NO:
• 63), WASTRHT (SEQ ID NO:
• 64), and QQYSSYPLT (SEQ ID NO:
• 65), respectively;
• b) a heavy chain with three CDRs comprising the amino acid sequences GNTFTSYTMH (SEQ ID NO:
• 69), YINPSSGYTEYNQKFKD (SEQ ID NO:
• 70), and GPRY (SEQ ID NO:
• 71), respectively, and a light chain with three CDRs comprising the amino acid sequences KASQNVGTNVA (SEQ ID NO:
• 72), SASYRYS (SEQ ID NO:
• 73), and QQYNSYPYT (SEQ ID NO:
• 74), respectively;
• c) a heavy chain with three CDRs comprising the amino acid sequences GYTFTSYWMH (SEQ ID NO:
• 145), EINPSNGRTNYNEKFKS (SEQ ID NO:
• 77), and DGGDY (SEQ ID NO:
• 78), respectively, and a light chain with three CDRs comprising the amino acid sequences KASQDVGTAVA (SEQ ID NO:
• 79), WASTRHT (SEQ ID NO:
• 80), and QQYSSYPLT (SEQ ID NO:
• 81), respectively;
• d) a heavy chain with three CDRs comprising the amino acid sequences GYTFTSYWIVH (SEQ ID NO:
• 85), EINPRNGRSNYNEKFKN (SEQ ID NO:
• 86), and DGGDY (SEQ ID NO:
• 87), respectively, and a light chain with three CDRs comprising the amino acid sequences KASQNVGTNVA (SEQ ID NO:
• 88), SASYRYS (SEQ ID NO:
• 89), and QQYNSYPLT (SEQ ID NO:
• 90), respectively;
• e) a heavy chain with three CDRs comprising the amino acid sequences GYTFTSYWIVH (SEQ ID NO:
• 94), EINPRNGRSNYNEKFKN (SEQ ID NO:
• 95), and DGGDY (SEQ ID NO:
• 96), respectively, and a light chain with three CDRs comprising the amino acid sequences KASQDVGTAVA (SEQ ID NO:
• 97), WASTRHT (SEQ ID NO:
• 98), and XQYXXYPLT (SEQ ID NO:
• 99), respectively;
• f) a heavy chain with three CDRs comprising the amino acid sequences GYAFTKYLIE (SEQ ID NO:
• 103), VINPGSGSTSYNEKFRY (SEQ ID NO:
• 104), and IPASYRSDSLDC (SEQ ID NO:
• 105), respectively, and a light chain with three CDRs comprising the amino acid sequences KASQDVGTAVA (SEQ ID NO:
• 106), WASTRHT (SEQ ID NO:
• 107), and QQYSSYPWT (SEQ ID NO:
• 108), respectively;
• g) a heavy chain with three CDRs comprising the amino acid sequences GYTFTKYLIE (SEQ ID NO:
• 112), VINPGSGSTSYNEKFRYK (SEQ ID NO:
• 113), and IPASYRSDSLDC (SEQ ID NO:
• 114), respectively, and a light chain with three CDRs comprising the amino acid sequences KASQDVGTAVA (SEQ ID NO:
• 115), WASTRHT (SEQ ID NO:
• 116), and QQYSSYPWT (SEQ ID NO:
• 117), respectively;
• h) a heavy chain with three CDRs comprising the amino acid sequences GYAFTKYLIE (SEQ ID NO:
• 121), VINPGSGSTSYNEKFRY (SEQ ID NO:
• 122), and IPASYRSDSLDC (SEQ ID NO:
• 123), respectively, and a light chain with three CDRs comprising the amino acid sequences KASQDVGTAVA (SEQ ID NO:
• 124), WASTRHT (SEQ ID NO:
• 125), and QQYKSYPLT (SEQ ID NO:
• 126), respectively;
• i) a heavy chain with three CDRs comprising the amino acid sequences GYVFTNFLIE (SEQ ID NO:
• 130), VINPGNGGAAYNEKFKG (SEQ ID NO:
• 131), and LPPSYDYDGDIDY (SEQ ID NO:
• 132), respectively, and a light chain with three CDRs comprising the amino acid sequences RASKSVTTSGYSLMH (SEQ ID NO:
• 133), PASNLES (SEQ ID NO:
• 134), and QHSRELPWT (SEQ ID NO:
• 135), respectively;
• or
• j) a heavy chain with three CDRs comprising the amino acid sequences GYAFTNFLIE (SEQ ID NO:
• 139), VINPGSGGTGYNEKFKG (SEQ ID NO:
• 140), and LPPSYDYDGDIDY (SEQ ID NO:
• 141), respectively, and a light chain with three CDRs comprising the amino acid sequences RASKSVSSSGYSLIH (SEQ ID NO:
• 142), LASNLXS (SEQ ID NO:
• 143), and XHSXXLPWX (SEQ ID NO:
• 144), respectively.