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US 11,028,448 B2Granted
Methods of identifying risk of vascular endothelial growth factor (VEGF) pathway inhibitor-induced hypertension
AssigneesThe University of North Carolina at Chapel Hill, Duke University
InventorsFederico Innocenti, Julia Quintanilha, Danyu Lin, Kouros Owzar, Jin Wang
Life of this patent
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Abstract
The disclosure relates to methods of identifying subjects at risk of developing bevacizumab-induced toxicities such as proteinuria and/or hypertension involving measuring nucleic acid or gene mutations in a sample obtained from the subject.
Claims6
A method for reducing the risk of vascular endothelial growth factor (VEGF) pathway inhibitor-induced hypertension in a subject in need of treatment with a VEGF pathway inhibitor, the method comprising:
- (i) identifying the subject as having a single nucleotide polymorphism (SNP) at rs6770663, wherein the base identified at rs6770663 is a guanine;
- and
- (ii) administering one or more antihypertensive agents to the subject identified as having a guanine at rs6770663.
Dependencies are inferred from the claim text.