Method for evaluating the risk of drug hypersensitivity reaction induced by Sulfamethoxazole and Trimethoprim

A method for treating an indication in a patient treatable by sulfamethoxazole and/or trimethoprim, comprising:

• evaluating the risk of developing a drug hypersensitivity reaction caused by sulfamethoxazole and trimethoprim in a patient with an indication treatable by sulfamethoxazole and trimethoprim, comprising the step of detecting the presence of HLA-B*1301 allele from a sample from the patient, wherein the presence of the HLA-B*1301 allele indicates the patient has a higher risk of developing drug hypersensitivity reaction caused by sulfamethoxazole and trimethoprim compared to a subject without the HLA-B*1301 allele;
• and thereafter
• based on the detecting the presence of HLA-B*1301 allele from the sample from the patient, administering an antibiotic other than sulfamethoxazole and/or trimethoprim in order to minimize the risk developing a drug hypersensitivity reaction caused by sulfamethoxazole and trimethoprim,
• wherein said patient is of Asian ancestry and said drug hypersensitivity reaction caused by sulfamethoxazole and trimethoprim is maculopapular eruption, fixed drug eruption, Stevens-Johnson syndrome, toxic epidermal necrolysis or drug rash with eosinophilia and systemic symptoms.