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AssigneesOsaka University, Knc Laboratories Co., Ltd., Aichi Medical University
InventorsYoshitaka Nagai, Kazuhiro Maeta, Toshihide Takeuchi, Masahiro Neya, Tsuyoshi Fujihara, Seiji Matsuda, Gen Sobue, Shinsuke Ishigaki, Kentaro Sahashi
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The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.
An antisense oligonucleotide targeting TAR DNA-binding domain 43 (TDP-43) mRNA, comprising a nucleotide sequence complementary to a sequence consisting of at least 15 continuous nucleotides in the nucleotide sequence of any of SEQ ID NOs:
An antisense oligonucleotide targeting TAR DNA-binding domain 43 (TDP-43) mRNA, comprising a nucleotide sequence complementary to a sequence consisting of at least 15 continuous nucleotides in the nucleotide sequence of SEQ ID NO:
Dependencies are inferred from the claim text.