Methods for enhancing utrophin production via inhibition of microRNA

A pharmaceutical composition comprising an antisense oligonucleotide that specifically hybridizes to a Let-7c microRNA binding sequence in a 3′-UTR of a utrophin mRNA 3′ untranslated region (UTR) and inhibits the binding of the Let-7c microRNA to the utrophin mRNA 3′-UTR and at least one pharmaceutically acceptable excipient, wherein the antisense oligonucleotide is present in an amount effective in a human subject to inhibit the binding of Let-7 micro RNA with its utrophin mRNA 3′-UTR binding sequence, and wherein the antisense oligonucleotide comprises the sequence of SEQ ID NO:

• 25 (5′-CUG AGG UAG AAA GGU GGU CAU GGC UU-3′).