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US 11,028,374 B2Granted
Methods for treating anemia in a subject in need thereof
AssigneeAcceleron Pharma Inc.
InventorsJasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
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Abstract
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Claims26
A method of treating anemia in a subject in need thereof, comprising subcutaneously administering to the subject a polypeptide comprising an amino acid sequence that is at least 90% identical to the sequence of amino acids 29-109 of SEQ ID NO:
- 1, wherein the polypeptide comprises an acidic amino acid at the position corresponding to position 79 of SEQ ID NO:
- 1, wherein the polypeptide binds to GDF11 and/or myostatin.
Dependencies are inferred from the claim text.