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US 11,028,185 B2Granted
Using sortases to install click chemistry handles for protein ligation
AssigneeWhitehead Institute for Biomedical Research
InventorsHidde L. Ploegh, Martin D. Witte, Nicholas C. Yoder
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Abstract
Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.
Claims20
A bispecific, chimeric antibody comprising
- a first antibody or antigen-binding antibody fragment comprising a sortase recognition sequence;
- and
- a second antibody or antigen-binding antibody fragment comprising a sortase recognition sequence;
- wherein the first and the second antibody or antibody fragment are conjugated together via click chemistry.
1 more element
Dependencies are inferred from the claim text.