Anti-transferrin receptor antibodies and uses thereof
AssigneeAvidity Biosciences, Inc.
InventorsBeatrice Diana Darimont, Venkata Ramana Doppalapudi, Rachel Johns
Life of this patent
Estimating the term…
Abstract
Disclosed herein, in certain embodiments, are anti-transferrin receptor antibodies, anti-transferrin receptor antibody conjugates, and pharmaceutical compositions which comprise the anti-transferrin receptor antibodies or conjugates. In some embodiments, also disclosed herein are methods of delivering a payload utilizing an anti-transferrin receptor antibody described herein, and methods of treatment with use of an anti-transferrin receptor antibody described herein.
Claims20
An antibody or antigen-binding fragment thereof that binds to transferrin receptor, wherein the antibody or antigen-binding fragment comprises i) a variable heavy chain (VH) region comprising a sequence selected from SEQ ID NOs:
- 13-16, and ii) a variable light chain (VL) region comprising a sequence selected from SEQ ID NOs:
- 18-21.
An anti-transferrin receptor antibody conjugate, comprising Formula (I):
- A-(X1—B)n Formula (I)
- wherein A comprises an anti-transferrin receptor antibody or antigen-binding fragment thereof, wherein the anti-transferrin receptor antibody or antigen-binding fragment thereof comprises a variable heavy chain (VH) region comprising a sequence selected from SEQ ID NOs:
- 13-16, and a variable light chain (VL) region comprising a sequence selected from SEQ ID NOs:
- 18-21;
- B comprises a polynucleic acid molecule;
- X1 consists of a bond or linker;
- and
- n is an averaged value selected from 1-12.
Dependencies are inferred from the claim text.