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AssigneeBiocon Limited
InventorsPradip Nair, Ramakrishnan Melarkode, Bala S. Manian, Abhijit Barve, Usha Bughani, Jose Enrique Montero Casimiro
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The present disclosure relates to methods for treatment and prevention of disease conditions mediated by T-helper 17 (Th17) and/or T-helper 1 (Th1) T lymphocytes (T cells). In particular, the present disclosure relates to use of anti-CD6 antibody for treatment of disease conditions mediated by auto-reactive Th17 and Th1 T lymphocytes. The methods of the present disclosure further have utility in methods for modulating an immune response by suppressing production of the cytokine IL-23R, thereby decreasing inflammation mediated by Th17 cells.
A method of treatment for an autoimmune disease in a subject, wherein the autoimmune disease is an Inflammatory Bowel Disease, the method comprising administering to the subject a binding partner that specifically binds to CD6, wherein the binding partner is a humanized antibody Itolizumab or a functional fragment thereof that specifically binds to D1 of CD6;
Dependencies are inferred from the claim text.