Albumin binding domain fusion proteins
AssigneeSonnet Bio Therapeutics
InventorsJohn K. Cini, Haomin Huang
Life of this patent
Estimating the term…
Abstract
Compositions that include an albumin binding domain and a fusion partner (e.g., a cytokine or a binding moiety) are provided. Such therapeutics have increased serum half-life and find use in applications where one or more such therapeutics are needed, for example, in oncology applications.
Claims17
A composition comprising an albumin binding domain (ABD), said ABD comprising:
- a) a variable heavy chain comprising a vhCDR1, a vhCDR2 and a vhCDR3 of a variable heavy chain having SEQ ID NO:
- 25;
- and
- b) a variable light chain comprising a vlCDR1, a vlCDR2 and a vlCDR3 of a variable light chain having SEQ ID NO:
- 29.
An albumin binding domain (ABD) fusion protein comprising an ABD attached to a fusion partner, wherein said ABD comprises a variable heavy chain comprising a vhCDR1, a vhCDR2 and a vhCDR3 of a variable heavy chain having SEQ ID NO:
- 25, and a variable light chain comprising a vlCDR1, a vlCDR2 and a vlCDR3 of variable light chain having SEQ ID NO:
- 29.
An ABD fusion protein according to the formula:
- (FP1)-L1-(ABD)-L2-(FP2),
- wherein ABD is an albumin binding domain comprising a variable heavy chain and a variable light chain;
- wherein FP1 and FP2 are a first fusion partner and a second fusion partner, respectively;
- wherein L1 and L2 are a first and second linker, respectively;
- where said variable heavy chain of said ABD comprises a vhCDR1, a vhCDR2 and a vhCDR3 of a variable heavy chain having SEQ ID NO:
- 25;
- and
- where said variable light chain of said ABD comprises a vlCDR1, a vlCDR2 and a vlCDR3 of a variable light chain having SEQ ID NO:
- 29.
Dependencies are inferred from the claim text.