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US 11,028,157 B2Granted
Binding molecules that specifically bind to tau
AssigneeJanssen Vaccines & Prevention B.V.
InventorsJaroslaw Juraszek, Constantin Adrian Apetri
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Abstract
The invention relates to binding molecules and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The invention also relates to diagnostic, prophylactic and therapeutic methods using the binding molecules or antigen-binding fragments.
Claims20
A binding molecule that is adapted to specifically bind to tau, comprising:
- a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1,
- a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2,
- a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3,
- a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4,
- a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and
- a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6,
- wherein the binding molecule is capable of inhibiting aggregation of tau.
10 more elements
Dependencies are inferred from the claim text.