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US 11,028,152 B2Granted
Single domain antibodies to Chikungunya virus
AssigneeThe Government of the United States of America, as represented by the Secretary of the Navy
InventorsJinny Lin Liu, George P. Anderson, Ellen R. Goldman
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Abstract
Described herein are single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Chikungunya Virus (CHIKV).
Claims6
An isolated antibody comprising a protein sequence selected from the group consisting of SEQ ID Nos. 1-14.
A method of detecting Chikungunya virus, comprising:
- contacting a sample known or suspected to contain Chikungunya virus with a bound or immobilized antibody that includes a protein sequence selected from the group consisting of SEQ ID Nos. 1-14 under conditions that permit antigen binding thereto;
- and
- rising the antibody to remove unbound reagents, wherein
- at least a portion of any Chikungunya virus in the sample remains bound to the antibody, thereby producing a response indicative of the presence of Chikungunya virus in the sample.
1 more element
Dependencies are inferred from the claim text.