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US 11,028,121 B2Granted
Multisignal labeling reagents and processes and uses therefor
AssigneeEnzo Life Sciences, Inc.
InventorsJack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Abstract
Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.
Claims8
A multi-signal labeling reagent, comprising:
- a plurality of first nucleic acid strands covalently bound to the first member of a binding pair and not to the second member of the binding pair;
- and
- a plurality of second nucleic acid strands covalently bound to a second member of the binding pair and not to the first member of the binding pair,
- wherein at least some of the nucleic acid monomers of one or both of the first nucleic acid strands and the second nucleic acid strands comprise a covalently linked signal moiety, and
- wherein the binding pair is not a nucleic acid binding pair.
2 more elements
Dependencies are inferred from the claim text.