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US 11,028,118 B2Granted
Efficient synthesis of nicotinamide mononucleotide
AssigneeCornell University
InventorsAnthony Sauve, Farheen Sultana Yang Mohammed
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Abstract
The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
Claims5
A process for the preparation of nicotinamide mononucleotide having formula (I):
- or a salt thereof, wherein the process comprises the step of reacting a compound of formula (IV):
- wherein R1 and R2 are independently C1-C6 alkyl or, taken together along with the carbon atom to which they are attached, form a 5-7 membered carbocyclic ring,
- with an acid catalyst in a mixture of solvents to provide nicotinamide mononucleotide,
- wherein the acid catalyst is trifluoroacetic acid, and
- wherein the mixture of solvents is a mixture of dichloromethane and water.
2 more elements
A process for the preparation of nicotinamide mononucleotide having formula (I):
- or a salt thereof, wherein the process comprises the step of reacting a compound of formula (IV):
- wherein R1 and R2 are independently C1-C6 alkyl or, taken together along with the carbon atom to which they are attached, form a 5-7 membered carbocyclic ring,
- with an acid catalyst in a solvent to provide nicotinamide mononucleotide,
- wherein the solvent is methanol, and
- wherein the acid catalyst is concentrated hydrochloric acid present in an amount of about 3% (volume/volume) relative to a volume of methanol.
2 more elements
Dependencies are inferred from the claim text.