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US 11,028,117 B2Granted
Bicyclic nucleosides and oligomers prepared therefrom
AssigneeUniversitäT Bern
InventorsChristian Leumann, Damien Evéquoz
Life of this patent
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Abstract
Oligomers can be prepared from bicyclic nucleosides. The nucleosides can be a compound of formula (I) in which each of T1 and T2 is independently OR1 or OR2; R1 is H or a hydroxyl protecting group, R2 is a phosphorus moiety; and Bx is a nucleobase. The compounds, bicyclic nucleosides and oligomers are useful for the prevention, treatment or diagnosis of muscular dystrophy.
Claims20
A compound of formula (I):
- wherein T1 and T2 are each independently selected from the group consisting of OR1 and OR2;
- and;
- wherein
- R1 is H or a hydroxyl protecting group, and
- R2 is a phosphorus moiety;
- and wherein
- Bx is a nucleobase.
4 more elements
An oligomer comprising at least one monomer subunit as a compound of formula (IV)
- wherein either T3 or T4 are independently a nucleosidic linkage group;
- and
- when T3 is a nucleosidic linkage group;
- T4 is selected from the group consisting of OR1, OR2, a 5′ terminal group, a 7′ terminal group and a nucleosidic linkage group, and
- when T4 is a nucleosidic linkage group;
- T3 is selected from the group consisting of OR1, OR2, a 5′ terminal group, a 7′ terminal group and a nucleosidic linkage group, and;
- wherein R1 is selected from H and a hydroxyl protecting group, and R2 is a phosphorus moiety;
- and
- Bx is a nucleobase.
6 more elements
Dependencies are inferred from the claim text.