Cyphomycin, compositions and uses thereof

A method of treating a fungal infection comprising administering to a mammal in need thereof an effective amount of a compound, or a pharmaceutical composition thereof, wherein:

• the compound is a compound of Formula I,
• or the compound is a compound of Formula IA,
• or the compound has the formula, C77H122O26 and exhibits one or more of the following spectral features:
• one or more 13C NMR peaks at or about the ppm chemical shifts in the table below;
• one or more 1H NMR peaks at or about the ppm chemical shifts in the table below;
• or
• one or more UV λmax at about 204, about 248, about 254, or about 334 nm;
• δC
• δH, mult. (J in Hz)
• δC
• δH, mult. (J in Hz)
• 168.7
• —
• 38.5
• 2.00, m
• 122.1
• 5.86, br d (15.8)
• 80.5
• 3.88,m
• 153.5
• 7.06, dd (15.8, 6.8)
• 22.9
• 1.64, m
• 1.36, m
• 43.5
• 2.47, m
• 11.5
• 0.98, t (7.2)
• 74.2
• 3.78,m
• 14.1
• 1.09, d (6.7)
• 41.7
• 1.60, m
• 13.6
• 0.79, d (6.4)
• 1.54, m
• 71.8
• 3.78, m
• 17.3
• 1.03, d (6.5)
• 38.9
• 1.32-1.62, m
• 9.7
• 0.90, d (6.8)
• 23.0
• 1.45-1.68, m
• 5.0
• 0.90, d (6.8)
• 38.5
• 1.32-1.62, m
• 10.6
• 0.78, d (6.4)
• 72.9
• 3.51, m
• 96.4
• 5.01, br s
• 36.4
• 1.38-1.47, m
• 37.9
• 1.93, dd (3.70, 14.0)
• 1.53-1.63 m
• 1.55, d (14.0)
• 31.9
• 1.69,m
• 71.2
• —
• 1.30, m
• 36.2
• 2.25, m
• 81.7
• 3.31, m
• 75.8
• 4.69, d (2.2)
• 64.7
• 4.44, m
• 210.6
• —
• 17.3
• 1.21, d (6.6)
• 99.4
• —
• 27.5
• 1.24, s
• 41.1
• 2.09,m
• 104.0
• 4.58, br d (7.6)
• 1.33, m
• 64.9
• 4.08, m
• 31.3
• 2.01, m
• 1.56, m
• 42.0
• 1.96, m
• 28.6
• 2.10, m
• 1.21,m
• 1.56,m
• 67.7
• 4.20, m
• 74.4
• 4.45, m
• 45.6
• 1.45-1.74, m
• 74.5
• 3.54, dq (6.1, 9.3)
• 65.4
• 4.08, m
• 18.5
• 1.19, d (6.1)
• 46.3
• 1.43-1.67, m
• 175.5
• —
• 68.2
• 4.04, m
• 48.9
• 2.78, dq (8.5, 7.1)
• 46.0
• 1.40-1.76, m
• 76.4
• 4.86, d (8.5)
• 71.3
• 3.79, m
• 150.3
• —
• 38.4
• 1.32-1.62, m
• 125.3
• 8.01, br s
• 22.7
• 1.51, m
• 133.5
• —
• 38.4
• 1.32-1.62, m
• 186.2
• —
• 72.4
• 3.94, m
• 136.5
• 6.88, br d (1.4)
• 135.2
• 5.53, dd (15.6, 4.5)
• 149.8
• —
• 133.1
• 5.49, dd (15.6, 7.2)
• 186.3
• —
• 40.4
• 2.54, m
• 132.9
• —
• 77.3
• 5.14, br d (9.5)
• 127.6
• 8.07, d (8.0)
• 38.7
• 1.97, m
• 133.2
• 7.79, dd (8.0, 1.3)
• 78.5
• 3.39, br d (9.5)
• 14.3
• 0.94, d (7.1)
• 36.0
• 1.81, m
• 16.4
• 2.17, s
• 79.4
• 3.52, m.