Inositol derivatives for use in pathological crystallization
AssigneesETH Zurich, UniversitäT Bern
InventorsMattias Ivarsson, Bastien Castagner, Jean-Christophe Leroux, Andreas Pasch
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Abstract
The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.
Claims22
A method for treatment of a condition associated with cardiovascular calcification, comprising administering to a subject in need thereof a compound described by a general formula (II)
- wherein
- one or two or three X are R1 and the remaining X independently from each other are selected from OPO32−, OPSO22−, and OSO3−;
- and
- each R1 independently of any other R1 is a polyethylene glycol or a polyglycerol,
- and wherein the condition is selected from the group consisting of coronary artery disease, vascular stiffening, valvular calcification, myocardial infarction, cardiovascular mortality, progression of chronic kidney disease, peripheral arterial disease, critical limb ischemia, calciphylaxis, general arterial calcification of infancy, aortic stenosis, atherosclerosis, pseudoxanthoma elasticum, cardiac hypertrophy, heart failure, arrhythmia, aneurysm, valvular stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation, stroke, and cognitive function.
A compound of general formula (II)
- wherein
- three X are R1 and the remaining X independently from each other X are selected from OPO32−, OPSO22−, and OSO3−;
- and
- each R1 independently of any other R1 is a polyethylene glycol or a polyglycerol.
Dependencies are inferred from the claim text.