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US 11,028,096 B2Granted
Tricyclic P2-ligand containing potent HIV-protease inhibitors against HIV/AIDS
AssigneePurdue Research Foundation
InventorsArun K. Ghosh, Hiroaki Mitsuya, Prasanth Reddy Nyalapatla
Life of this patent
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Abstract
Various embodiments relate to a compound of the formula (I) and (II), wherein X, X1, X2, X3, and R1-R4 are defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and/or (II) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I) and/or (II), or a pharmaceutical composition comprising compounds of the formula (I) and/or (II), to a patient in need thereof.
Claims16
A compound of the formula (I)
- or a pharmaceutically acceptable salt, polymorph, or solvate thereof, wherein:
- n is an integer from 0 to 3;
- X is (—CHR5—)m or —O—, wherein m is 1 or 2 and each R5 is, independently H, alkyl or alkoxy;
- X1, X2, and X3 are each, independently, (—CHR5—)m;
- R1 is alkyl, alkoxy, aryl, heterocycyl, halo, hydroxy or amino;
- R2 is alkyl;
- R3 is aryl, benzthiazole, benzoxazole, benzofuranyl or indolyl;
- and
- R4 is H, alkyl or alkoxy.
6 more elements
Dependencies are inferred from the claim text.