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US 11,028,091 B2Granted
Method for producing 3, 6-disubstituted imidazo[1, 2-b]pyridazine derivative
AssigneeDaiichi Sankyo Company, Limited
InventorsRyoji Koike, Yoshifumi Hachisu, Takafumi Kitawaki, Shohei Shiraishi
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Abstract
Provided is a novel and industrially useful method for producing a 3, 6-disubstituted imidazo[1, 2-b]pyridazine derivative. The present invention provides a method for producing a 3, 6-disubstituted imidazo[1, 2-b]pyridazine derivative, which uses 6-fluoroimidazo[1, 2-b]pyridazine as a starting material, while using an aromatic substitution reaction that utilizes C—H activation by means of palladium.
Claims5
A method for producing a compound represented by Formula (III) or a salt thereof:
- wherein PG represents a protecting group for a nitrogen atom, the method comprising reacting a compound represented by Formula (I) or a salt thereof:
- with a compound represented by Formula (II) or a salt thereof:
- wherein each symbol is as defined above, in a solvent in the presence of a palladium catalyst and a base.
Dependencies are inferred from the claim text.