Back to results
US 11,028,089 B2Granted
Pyrimido-diazepinone kinase scaffold compounds and methods of treating DCLK1/2-mediated disorders
AssigneeDana-Farber Cancer Institute, Inc.
InventorsFleur M. Ferguson, Nathanael S. Gray
Life of this patent
Estimating the term…
Abstract
The present invention relates to use of pyrimido-diazepinone compounds that are able to modulate protein kinases such as doublecortin-like kinase (DCLK1) and doublecortin-like kinase 2 (DCLK2), which are members of serine/threonine-protein kinase family and Ca2+/calmodulin-dependent protein kinase class of enzymes, and the use of such compounds in the treatment of various diseases, disorders or conditions.
Claims11
A method of treating pancreatic cancer in a subject, the method comprising administering to the subject a compound of formula F-1:
- or a pharmaceutically acceptable salt thereof,
- wherein,
- R1 is
- R2 is —CH2—CH2F, —CH2—CHF2, or —CH2—CF3;
- R5 is hydrogen or methyl;
- and
- R6 is hydrogen or optionally substituted alkyl;
- each R7 is independently alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heterocyclic, carbocyclic, alkoxy, NH(alkyl), NH(aryl), N(alkyl)(alkyl), or N(alkyl)(aryl), each of which may be optionally substituted;
- halo, nitro, or cyano;
- and
- p is 0-4.
8 more elements
A compound of formula F-1:
- or a pharmaceutically acceptable salt thereof,
- wherein,
- R1 is
- R2 is —CH2—CH2F, —CH2—CHF2, or —CH2—CF3;
- R5 is hydrogen or methyl;
- and
- R6 is hydrogen or optionally substituted alkyl;
- each R7 is independently alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heterocyclic, carbocyclic, alkoxy, NH(alkyl), NH(aryl), N(alkyl)(alkyl), or N(alkyl)(aryl), each of which may be optionally substituted;
- halo, nitro, or cyano;
- and
- p is 0-4.
8 more elements
A compound which is:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.