Process for the preparation of a novel umeclidinium synthesis intermediate
AssigneeOlon S.P.A.
InventorsGiorgio Bertolini, Corrado Colli, Filippo Nisic, Mara Sada, Stefania Bertuolo, Silvano Ronzoni, Stefano Maiorana, Romano Di Fabio
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Abstract
The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.
Claims14
A Process for the preparation of a compound of formula (I) or one of its salts
- which comprises reacting a compound of formula (II)
- with a compound selected from phenyl lithium and phenyl magnesium bromide, in a suitable solvent, optionally isolating the so-obtained compound of formula (I) and optionally transforming it into one of its salts.
A method of preparing the compound of formula (I) and/or umeclidinium using the compound of formula (II) and/or the compound of Formula (III) as intermediates
A compound of formula (II)
- or one of its salts.
Dependencies are inferred from the claim text.