Substituted pyrimidines as LRKK2 inhibitors

A compound of formula (I):

• or a pharmaceutically acceptable salt, deuterated isotope, or stereoisomer thereof,
• wherein:
• m is 1 or 2;
• ring A is isothiazolyl or thiazolyl;
• R1 is halo, cyano, C1-6 alkyl, or C1-6 haloalkyl;
• R2 is N(R5)(R6), C1-6 alkoxy, or cycloalkyl;
• each R3 is independently H, halo, cyano, C1-6 alkyl, C6 haloalkyl, C1-6 cyanoalkyl, C1-6 aminoalkyl, amidoalkyl, C1-6 hydroxyalkyl, C1-6 alkoxyalkyl, C(O)R7, amido, N(R16)2, C1-6 alkylsulfonyl, C1-6 alkylsulfonylalkyl, cycloalkylalkyl, heterocyclylalkyl, alkytheterocyclylalkyl, arylalkyl, heteroarylalkyl, alkylheteroarylalkyl, cycloalkyl, cyanocycloalkyl, heteroarylcycloalkyl, alkylheteroarylcycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein each C1-6 alkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C1-6 aminoalkyl, C1-6 hydroxyalkyl, C1-6 alkoxyalkyl, C1-6 alkylsulfonyl, C1-6 alkylsulfonylalkyl, cycloalkylalkyl, heterocyclylalkyl, alkylheterocyclylalkyl, arylalkyl, heteroarylalkyl, alkylheteroarylalkyl, cycloalkyl, cyanocycloalkyl, heteroarylcycloalkyl, alkylheteroarylcycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally and independently substituted with one or more substituents independently selected from the group consisting of oxo, thioxo, halo, cyano, hydrazino, azido, nitro, alkyl, haloalkyl, hydroxyalkyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl, heteroarylalkyl, alkenyl, alkynyl, imino, hydrazone, amidino, oxime, C(O)H, amido, imido, carboxy, C(O)Oalkyl, amino, guanidino, NHC(O)Oalkyl, hydroxy, alkoxy, haloalkoxy, OC(O)NH2, thiol, thiocyanate, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfonamido, sulfinic acid, sulfonic acid, cycloalkyl, heterocyclyl, aryl, heteroaryl, and Si(RY)3;
• R5 is H, C1-6 alkyl, C1-6 haloalkyl, or cycloalkyl;
• R6 is H, C1-6 alkyl, C1-6 haloalkyl, or cycloalkyl;
• each R7 is independently C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, or heterocyclyl, wherein each C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, and heterocyclyl is optionally and independently substituted with one or more substituents independently selected from the group consisting of halo, cyano, hydroxy, C1-6 alkoxy, and C1-6 alkylsulfonyl;
• each R16 is independently H or C1-6 alkyl, wherein each C1-6 alkyl is optionally and independently substituted with one or more substituents independently selected from the group consisting of halo, cyano, hydroxy, C1-6 alkoxy, and C1-6 alkylsulfonyl;
• and
• each RY is independently H, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• with the proviso that if R5 or R6 is cycloalkyl, then ring A is not isothiazolyl.