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AssigneeGuangdong Longfu Medicine Co., Ltd.
InventorsZhangjian Huang, Tao Pang, Cunfang Wang, Wenbin Zeng, Jinxiang Deng, Weijie Wu, Tingyu Huang
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The invention discloses a butylphthalide-telmisartan heterocomplex, a preparation method and an application thereof. The invention specifically relates to an optically active ring-opening butylphthalide-telmisartan heterocomplex shown in formula I or a pharmaceutically acceptable salt or ester thereof, a preparation method thereof, a pharmaceutical composition containing the compounds, and a pharmaceutical application thereof, particularly application in prevention and treatment of neuroinflammation-related diseases, including ischemic stroke, Alzheimer's disease, brain trauma, Parkinson's disease, multiple sclerosis, depression and so on.
A compound which is an optically active butylphthalide-telmisartan hybrid as shown in general formula I, or an optical isomer, an enantiomer, a diastereomer, a racemate or a racemic mixture thereof, or a pharmaceutically acceptable salt thereof:
A compound or an optical isomer, an enantiomer, a diastereomer, a racemate or a racemic mixture thereof, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
Dependencies are inferred from the claim text.