2,4-diamino-6-ethylpyrimidine derivatives with antimalarial activities against Plasmodium falciparum

Derivatives of 2,4-diamino-6-ethylpyrimidine of Formula (I):

• Wherein X1, X2 are oxygen or absent, Y1, Y2 are (CH2)1-3alkyl or absent, Z is (1-substituted-1H-1,2,3-triazol-4-yl) ring, (3-(substituted(isoxazol-5-yl) ring, (2-(substituted(oxazol-4-yl) ring, (2-(substituted)thiazol-4-yl) ring;
• wherein Ar is an aromatic ring or substituted aromatic ring as below:
• a. Z is a ring of (1-substituted-1H-1,2,3-triazol-4-yl);
• Ar is phenyl or carboxyl substituted phenyl;
• no group X1, X2, Y1 and Y2
• b. Z is a ring of (1-substituted-1H-1,2,3-triazol-4-yl);
• Ar is phenyl, carboxymethyl substituted phenyl, carboxyl-substituted phenyl or diphenylcarbamoyl substituted phenyl;
• Y2 is C1-3 alkyl;
• no group X1, X2 and Y1
• c. Z is a ring of (1-substituted-1H-1,2,3-triazol-4-yl);
• Ar is chloro-substituted phenyl or carboxymethyl-substituted phenyl;
• X2 is oxygen;
• Y2 is C2-3 alkyl;
• no group X1 and Y1
• d. Z is a ring of (3-(substituted)isoxazol-5-yl);
• Ar is phenyl, fluoro-substituted phenyl, chloro-substituted phenyl, bromo-substituted phenyl, trifluoromethyl-substituted phenyl, methoxy-substituted phenyl, nitro-substituted phenyl, cyano substituted phenyl, carboxymethyl-substituted phenyl or carboxyl-substituted phenyl;
• X1 is oxygen;
• Y1 is C1-3 alkyl;
• no group X2 and Y2
• e. Z is a ring of (2-(substituted)oxazol-4-yl);
• Ar is phenyl, chloro-substituted phenyl, methyl-substituted phenyl, nitro-substituted phenyl, alkoxy carbonylmethoxy substituted phenyl, carboxymethoxy-substituted phenyl, alkoxy carbonyl-substituted phenyl or carboxy-substituted phenyl;
• X1 is oxygen;
• Y1 is C1-2 alkyl;
• no group X2 and Y2
• f. Z is a ring of (2-(substituted)thiazol-4-yl);
• Ar is phenyl, fluoro-substituted phenyl, chloro-substituted phenyl, bromo-substituted phenyl, methyl-substituted phenyl, m ethoxy-substituted phenyl, nitro-substituted phenyl, alkoxy carbonylmethoxy substituted phenyl, carboxymethoxy-substituted phenyl, alkoxy carbonyl-substituted phenyl or carboxyl-substituted phenyl;
• X1 is oxygen;
• Y1 is C1-2 alkyl;
• no group X2 and Y2.