Indazole derivatives as alpha v integrin antagonists

A compound of Formula (Ia) or (Ib):

• wherein:
• A, E, G, and J are independently N, C, or CH with the provisos that one of A, E, G, and J is N and one of A, E, G, and J is C attached to Y;
• X is a C1-4 alkylene substituted with 0, 1, or 2 R8a;
• Y is a covalent bond or O;
• R1 is:
• R2 is hydrogen, halo, or C1-6 alkyl;
• R3 is hydrogen, C1-6 alkyl, 3- to 10-membered carbocyclyl, carbocyclylalkyl, 6- to 10-membered aryl, arylalkyl, 3- to 14-membered heterocyclyl, heterocyclylalkyl, 5- to 14-membered heteroaryl, or heteroarylalkyl, wherein the alkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl, by themselves or as part of another group, are each independently substituted with 0, 1, 2, or 3 R6;
• R3a is hydrogen;
• R4 is hydrogen, C1-6 alkyl, 3- to 10-membered carbocyclyl, carbocyclylalkyl, 3- to 10-membered heterocyclyl, heterocyclylalkyl, 6- to 10-membered aryl, arylalkyl, 5- to 14-membered heteroaryl, heteroarylalkyl, —S(O)mR7, —C(O)NRaRb, —NHC(O)ORa, —NHC(O)NRaRb, —OC(O)NRaRb, —OC(O)R7, —NHS(O)mNRaRb, or —NHS(O)mR7;
• wherein the alkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl, by themselves or as part of another group, are each independently substituted with 0, 1, 2, or 3 R9;
• R5 is hydrogen, R5a, or a structural moiety selected from
• L1 and L2 are each independently C1-4 alkylene;
• R5a and R5b are each independently C1-6 alkyl, phenyl, benzyl, or 5- to 7-membered heterocyclyl;
• wherein the alkyl, phenyl, and heterocyclyl are each independently substituted with 0 to 3 R5′;
• R5c is C1-6 alkyl or 5- to 7-membered carbocyclyl;
• wherein the C1-6 alkyl, and heterocyclyl are each independently substituted with 0 to 3 R5d;
• R5d, at each occurrence, is independently halo, OH, alkoxy, oxo, or alkyl;
• or alternatively, two adjacent R5d, together with the atoms to which they are attached, form a carbocyclyl moiety;
• R6 is halo, cyano, hydroxyl, amino, oxo, nitro, —S(O)mR12, C1-6 alkyl, alkoxy, haloalkyl, haloalkoxy, haloaminoalkyl, hydroxyalkyl, aminoalkyl, alkoxycarbonyl, 6- to 10-membered aryl, aryloxy, arylalkoxy, 5- to 10-membered heteroaryl, 3- to 6-membered carbocyclyl, or 3- to 7-membered heterocyclyl;
• wherein the alkyl, aryl, heteroaryl, carbocyclyl, or heterocyclyl, by themselves or as part of another group, are each independently substituted with 0, 1, or 2 R10;
• R7 is each independently C1-6 alkyl, C1-6 alkoxy, C1-6 aminoalkyl, C1-6 haloalkyl, 6- to 10-membered aryl, arylalkyl, 5- to 10-membered heteroaryl, cycloalkyl, or heterocycloalkyl;
• wherein the alkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, by themselves or as part of another group, are each independently substituted with 0, 1, 2, or 3 R11;
• R9 is each independently halo, cyano, hydroxyl, amino, oxo, nitro, C1-6 alkyl, alkoxy, haloalkyl, haloalkoxy, haloaminoalkyl, hydroxyalkyl, aminoalkyl, alkoxycarbonyl, 6- to 10-membered aryl, aryloxy, arylalkoxy, 5- to 10-membered heteroaryl, 3- to 6-membered carbocyclyl, or 3- to 7-membered heterocyclyl;
• wherein the alkyl, aryl, heteroaryl, carbocyclyl, or heterocyclyl, by themselves or as part of another group, are each independently substituted with 0, 1, or 2 R13;
• R10 is halo, cyano, hydroxyl, amino, oxo, C1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, or sulfonamide;
• R11, at each occurrence, is independently halo, cyano, hydroxyl, amino, oxo, C1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, or haloalkoxy;
• R12 is —N(RxRy)C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, or C1-6 aminoalkyl;
• R13 is halo, cyano, hydroxyl, amino, oxo, C1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, or sulfonamide;
• Ra and Rb, at each occurrence, are independently hydrogen, C1-6 alkyl, C1-6 haloalkyl, C3-6 cycloalkyl, 6- to 10-membered aryl, 5- to 10-membered heteroaryl, cycloalkylalkyl, arylalkyl, heteroarylalkyl, or alkoxyalkyl;
• or alternatively, Ra and Rb, taken together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic or heterocyclic ring;
• wherein the aryl and heteroaryl, by themselves or as part of another group, are each independently substituted with one or more groups independently selected from halo, cyano, hydroxyl, amino, C1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, and sulfonamide;
• and the carbocyclyl and heterocyclyl, by themselves or as part of another group, are each independently substituted with one or more groups independently selected from halo, cyano, hydroxyl, amino, oxo, C1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, and sulfonamide;
• Re is OH, amino, amido, carbamate, sulfonamide, C1-4 alkyl, halo, C1-4 haloalkyl, or C3-6 cycloalkyl;
• Rx and Ry are each independently hydrogen or C1-6 alkyl;
• m is an integer of 1 or 2;
• r is an integer of 0, 1, 2, or 3;
• and
• or a pharmaceutically acceptable salt thereof.