Salt of substituted piperidine compound
AssigneeTaiho Pharmaceutical Co., Ltd.
InventorMorihiro Mitsuya
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Abstract
An object of the present invention is to provide a salt of the compound 1-(2,3-dichlorobenzoyl)-4-((5-fluoro-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)piperidine-4-carboxylic acid, useful as an antitumor agent, and crystals thereof which are excellent in solubility, stability, and oral absorption and can be produced in large quantities. The present invention relates to a hydrochloride salt of 1-(2,3-dichlorobenzoyl)-4-((5-fluoro-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)piperidine-4-carboxylic acid and crystals of the hydrochloride salt having characteristic peaks at particular diffraction angles in powder X-ray diffraction spectrum.
Claims9
A hydrochloride salt of 1-(2,3-dichlorobenzoyl)-4-((5-fluoro-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)piperidine-4-carboxylic acid,
- wherein the salt is a crystal having characteristic peaks at at least 3 or more diffraction angles (2θ±0.2°) selected from 12.83°, 13.54°, 16.20°, 18.27°, 23.80°, 29.10°, and 32.83° in powder X-ray diffraction spectrum.
Dependencies are inferred from the claim text.